I think it's a mistake to say "oh this game is an obvious blowout and he can't do well". If it's a blowout they scored points, and how did they accumulate those points? Through their best offensive weapon.

The Browns have one of the better run defenses in the league and below average pass defense. Also sharp bettors actually had the Browns, that didn't work out, but the line came back towards them at close. I believe the Texans also had the highest total on the slate, but that may have changed when the Browns were getting bet at the end -- either way they were projected for 27-30 points, and Hopkins likely makes up about 1/3 of that TD equity.

Think Hopkins was a great play, even in hindsight, and it's just bad luck that he got 13.8% of the targets yesterday when he garnered roughly 37% the previous 4 games.