Funny that you ask for that. I am dealing with 2 patients with mitochondrial disease. Allow me to share one story. A young girl presents with chest pain. Cardiologist does a cath and busts her coronary. Emergency bypass is needed. She is very sick and am called to consult. I suspect autonomic dysfunction and opt to see her once we get her better enough. So she comes the office and we conduct testing confirming POTS. Then the search for the cause begins and goes on for months. We narrow this down to possible mitochondrial disease and send blood to Duke for genetic analysis. Nearly one year later we get confirmation of OPA 1 gene deletion. Treatment has been complex.