There are lots of species of toads but one the most venomous toad in the world is Bufo alvarius .Bufo alvarius is very rare species of toad native to the Sonoran Desert, Bufo alvaries release a venom called 5 MEO DMT from the skin glands : an extremely potent natural psychedelic. Shamans have been harvesting and smoking the substance for decades, and thousands of people flock to the desert every year to sample it.