ARNIs are specifically indicated for patients with HFrEF, where the heart muscle's ability to pump blood is reduced. They are prescribed to improve cardiac function, reduce symptoms, and enhance the quality of life for patients with this type of heart failure. Vymada 100mg Tablet is a medication that contains a combination of sacubitril and valsartan, making it an angiotensin receptor-neprilysin inhibitor (ARNI). This dual mechanism of action contributes to improved cardiac function, reduced symptoms, and a better quality of life for patients with heart failure.