I went to university in London, and we used to go to Fabric quite regularly. It excelled in providing a reasonably priced, central location for revellers to dance away the night to eclectic, independent music created by an ever-rotating roster of both well-known and up-and-coming DJ's. Acoustically and atmospherically, Fabric was way way ahead of its time. Certainly opened my musical eyes in multiple ways that I still draw on today. This just makes me very sad, and while I don't want to rant, this just seems so typical of the bland, manufactured musical age that we appear to live in today.
The Guardian has a good article on the cultural significance of Fabric:
https://www.theguardian.com/music/2016/sep/07/fabric-closure-dance-music-london-nightlife
And DJ Goldie says it more eloquently here than I ever could
https://www.facebook.com/channel4newsidentity/videos/1178393192233438/