By a News Reporter-Staff News Editor at Women’s Health Weekly -- Research findings on Peptides and Proteins are discussed in a new report. According to news reporting from Taichung, Taiwan, by NewsRx journalists, research stated, “The family of matrix metalloproteinases (MMPs) controls homeostasis of the extracellular matrix and their genetic polymorphisms may be associated with personal cancer susceptibility. The serum levels of MMP8 was reported to be higher in patients with breast cancer than in healthy individuals.”
The news correspondents obtained a quote from the research from Asia University, “In this study, we aimed to investigate the contribution of a polymorphism in the promoter region of MMP8 (-799C/T) and two nonsynonymous polymorphisms (Val436Ala and Lys460Thr) to breast cancer. MMP8 -799C/T, Val436Ala and Lys460Thr polymorphic genotypes were determined for 1,232 patients with breast cancer and 1,232 healthy controls by polymerase chain reaction-restriction fragment length polymorphism methodology. The odds ratios (ORs) after adjusting for age, gender, smoking and alcohol drinking status for those carrying CT and TT genotypes at the MMP8 promoter C-799T were 1.03 (95% CI=0.88-1.23, p=0.7475) and 1.08 (95% CI=0.91-1.53, p=0.3561), respectively, compared to those carrying the wild-type CC genotype. The OR for the combined T-bearing genotypes were of a similar non-significant level (OR=1.05, 95% CI=0.90-1.26, p=0.5176). Supporting this finding, the adjusted OR for those carrying the T allele at MMP8 C-799T was 1.05 (95% CI=0.86-1.21, p=0.3797), compared to those carrying the wild-type C allele. There was also no significant association of MMP8 Lys460Thr with breast cancer. There was no polymorphic genotype at MMP8 Val436Ala found among any of the investigated individuals.”
According to the news reporters, the research concluded: “MMP8 -799C/T, Val436Ala and Lys460Thr polymorphisms may only play an indirect role in determining personal cancer susceptibility to breast cancer in Taiwan.”
For more information on this research see: The Association of Matrix Metalloproteinase-8 Promoter Genotypes in Breast Cancer. Anticancer Research , 2018;38(4):2181-2185. Anticancer Research can be contacted at: Int Inst Anticancer Research, Editorial Office 1ST Km Kapandritiou-Kalamou Rd Kapandriti, PO Box 22, Athens 19014, Greece. (International Institute of Anticancer Research - http://www.iiar-anticancer.org/; Anticancer Research - http://www.iiar-anticancer.org/main.php?id=2)
Our news journalists report that additional information may be obtained by contacting D.T. Bau, Asia Univ, Dept. of Bioinformat & Med Engn, Taichung, Taiwan. Additional authors for this research include L.C. Liu, T.C. Shih, C.L. Chuang, G.L. Chen, H.C. Wang, S.Y. Pan, T.C. Shen, C.W. Tsai, W.S. Chang, T.D. Way, J.G. Chung and C.L. Hsiao.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2018, NewsRx LLC
CITATION: (2018-04-26), Studies from Asia University Further Understanding of Peptides and Proteins (The Association of Matrix Metalloproteinase-8 Promoter Genotypes in Breast Cancer), Women’s Health Weekly, 367, ISSN: 1532-4729, BUTTER® ID: 015526696
From the newsletter Women’s Health Weekly.
https://www.newsrx.com/Butter/#!Search:a=15526696
This is a NewsRx® article created by NewsRx® and posted by NewsRx®. As proof that we are NewsRx® posting NewsRx® content, we have added a link to this steemit page on our main corporate website. The link is at the bottom left under "site links" at https://www.newsrx.com/NewsRxCorp/.
We have been in business for more than 20 years and our full contact information is available on our main corporate website.
We only upvote our posts after at least one other user has upvoted the article to increase the curation awards of upvoters.
NewsRx® offers 195 weekly newsletters providing comprehensive information on all professional topics, ranging from health, pharma and life science to business, tech, energy, law, and finance. Our newsletters report only the most relevant and authoritative information from qualified sources.