Yes, motherboards with the PCI-e slots are the one you want but finding the ones that have 5, 6 or 7 slots are hard to find. Biostar and Asrock BTC boards are the best but h270 pro4 can handle 5 slots and with M.2. you can add two more. I currently have GTX 1060s running. Very stable cards but has rate only around 22-25 MH/s. My RX570 are great at 26-30 MH/s. Have order for 5 more cards but who knows when they will come.