This image is a modern take on one of the most famous images in Buddhist art, the Wheel of Life or Bhavachakra. The form is one that has been copied throughout the history of Buddhism and in every nation where the religion has spread to.
It is essentially a visual representation of Buddhist cosmology, that is to say, a picture of the world and all of existence from the perspective of the Buddhist teachings. The six main sections into which the circle is divided represent the six realms of rebirth. In traditional renderings these would be the realms of Gods, demigods, humans, ghosts, animals and hells. If you believe in reincarnation then you can see this a literal sense, as places you can actually be reborn after you die, but even if you don't this image shows that, in principle, life is a spectrum ranging from very good to very bad conditions, and this is true wherever you look.
At the very top of the wheel is the White House, or it could be a royal palace, signifying the peak of wealth and luxury possible in the physical world. Just below that we have a McMansion with a swimming pool and its owner playing golf. In the original paintings this would be the realm of the Gods. In the level just below are the middle classes, representing the demigods, and below them the working classes, representing humans, whose life is characterised by struggle and hard work.
This is the top half of the wheel of life, the so called fortunate rebirths. In the bottom half are the unfortunate rebirths. On one side you have the government projects, and people living on welfare, as well as the homeless and tent cities, and probably people bankrupt or in debt. In the original paintings this would be the realm of the so-called "hungry ghosts", undead beings who are tormented by, for example, having huge bellies and tiny mouths, so no matter how much they ate they could never be satisfied. On the other side you have the animals, some of which get to live in relative comfort, but most live in a hell on earth in factory farms, and end their lives in a slaughterhouse. At the bottom we have the real hells, riots, societal collapse, mental institutions, and maximum security prisons.
At the centre of the image are the three root poisons that keep this wheel turning, greed, represented by the dollar bill, hatred, represented by the tank, and delusion, represented by the TV set.
I think it's important to reflect on this image for a number of reasons. We live in a culture that only wants to look at what is positive, but not the negative, but this is not reality. It is also a very selfish way of thinking, as it means you are ignoring the suffering of other beings, whose place you could very easily be in. A reminder of this is the character in the centre receiving a pink slip, falling into the gutter, then climbing back up the social ladder onto the red carpet and into a private jet, and then back again.
What this image teaches us is that wisdom means to look at the whole spectrum of existence, and realise that whatever we are chasing here is temporary, and wherever we are in the cycle of existence, we are not free until we are outside of it. The giant demon holding the wheel is Mara, the King of Death, here depicted as Uncle Sam, and to escape him we must let go of our attachment to material things, to wealth, success, fame, possessions and so on. These things only trap us deeper in the cycle.
The Buddhas shown outside of this wheel have escaped because they have renounced the world and all attachment to it, and by doing so they have attained peace. They have seen that there is no point in chasing after wealth, success and being attached to this material world, it is an illusion, and you can lose it all overnight, and you will lose it eventually. This is the middle path in Buddhism, and what the Four Noble Truths teach. Life is suffering, the cause of suffering is craving, enlightenment is the end of suffering, and the way to enlightenment is the practice of wisdom, morality and concentration.
https://ultraculture.org/blog/2015/04/03/buddhist-mandala-american-life/