Calcineurin inhibitors (CNIs) belong to the class of medications called immunosuppressants. They are used in management of autoimmune conditions and mainstays for immunosuppression in solid organ transplants.
Calcineurin inhibitors and their uses and applications
One of the first calcineurin inhibitors to be developed was cyclosporine (Cyclosporine A).
Tacrolimus (also known as FK506) is another calcineurin inhibitor used primarily in organ transplantation. It is considered an alternative to cyclosporine and is often used when cyclosporine is not well-tolerated or is ineffective.