Over the next few weeks i will blog on my experience with high dose vitamin B1. I have had chronic fatigue for about 20 years and recently read an article out of Italy with some success using high dose B1. I am starting with 3 500mg tablets a day with food. Each tablet says it provides 33,000 % DV ( daily value or government recommended amount). This is my 4th day on about 1500mg and not really affected me as of yet. I'll keep you posted.