Ethereum without a question... ONLY considering the here and now (with incoming diff. bomb and PoS). 6 x 480's @ 30mh/s each will net you probably a bit under 2 eth a week. Though, I hope that the ETC will be profitable to mine after ETH becomes undesirable to mine.

If your just trying to mine for fun on your home computer download the nicehash miner and see what it picks to mine for you. My guess is that it roughly selects something that mines the most for you (I'm assuming efficiency noyt considered :3).