Remember back four years ago I wrote a write up on a rare genetic mutation among German, Dutch and Newfoundland ancestry called arrhythmogenic right ventricular, well today watching a video on the news, researcher at Michigan State University and PLN Heart Foundation announced a rare genetic heart condition among Dutch families that they should know about. They have labeled the heart failure as phospholamban, and warned that they are "now urging those of Dutch ancestry who may have family who died unexpectedly or had unexpected heart failure to contact researchers." Arrhythmogenic right ventricular involves the proteins around the heart, as such, those with the genetic defect, the covid spike proteins can disrupt those proteins, and now, for the first time, it's possible to find the link around unknown causes of death during the roll out. They want anybody who had a family member who died unexpectedly or had unexpected heart failure to contact them. I think, in the end, they will get a lot more phone calls than they expect because this goes way beyond those who rose as unknown causes of death after the vaccine roll out to the number one cause of death, but the Dutch, German and Newfoundland family ancestries as well.
Here's the article:
Do you have Dutch ancestry? A rare gene mutation could affect your heart
There is a rare gene mutation linked to sudden cardiac death and heart failure called phospholamban (PLN). It may not be very common worldwide, but likely more so in West Michigan, as it is particularly prevalent among those with Dutch ancestry.
"Unlike other genetic diseases, it presents relatively late in life, maybe 40s and 50s," said Dr. Charles Hong, chair of the department of medicine at MSU College of Human Medicine. "So people don't realize that it's an inherited condition. We really don't know how many people are affected."
Now, medical professionals are raising awareness about the mutation, especially in West Michigan, where there is a large population with Dutch ancestry. It was traced to Frisian ancestors 700 years ago.
"It's a rare condition generally in the world; it's fairly rare, but here, we're not sure it's going to be so rare," said Dr. Allison Kuipers, vice chair of basic and translational research in the department of medicine at MSU College of Human Medicine.
On Wednesday, Michigan State University College of Human Medicine hosted Corewell Health and the Dutch PLN Heart Foundation for a symposium on the PLN gene mutation.
"I think the first thing is to identify the patients with this mutation, so that they could actually get better treatment and have preventative measures as well," said Hong.
The PLN gene mutation was discovered in 2006. According to the PLN Heart Foundation, only 120 people know they are a carrier; however, there are likely many more who have never been tested. There is a 50% chance of passing on the disease.
Pieter Glijnis initiated the Dutch PLN Heart Foundation after his life changed during a trip to Singapore.
"They had to defibrillate me 40 times," said Glijnis. "I was lucky."
Glijnis spent the next seven years of his life sick with heart failure. He also had an LVAD to help pump his heart. A year before he finally had a heart transplant, he learned about the PLN gene mutation.
"My brother wrote in his agenda, 'I need to be tested.'" said Glijnis. "And at the end of 2011, my brother went to work, and he never returned home alive."
Doctors in West Michigan are now urging those of Dutch ancestry who may have family who died unexpectedly or had unexpected heart failure to contact researchers.
"We want to raise awareness, and so that when a clinical trial comes along, that it is a very specific, personalized therapy, then we have everybody at hand," said Hong. "So that we don't go around searching for people. Having people be ready for this when the eventual cure comes around."
Here is my hive post from four years ago: @sunlit7/ancestral-genetic-mutation-could-be-the-cause-of-death-among-vaccinated-athletes-and-deaths-labeled-unknown-case-of-death
Here's how to contact Dr Charles Hong:
Chair of Medicine
MSU Research Foundation Distinguished Professor
Department of Medicine
Division of Cardiology
Professor
Clinic Address: MSU Health Care Heart and Vascular Center, 4660 S. Hagadorn Rd., Suite 600, East Lansing, 48823
Clinic: 517-267-2460
Academic Address: Clinical Center 788 Service Rd Room B425 East Lansing MI 48824
Academic: 517-432-9124
Here is how you contact Dr Pietr Glijnis at PLN Heart Foundation by email on their site:
https://plnfoundationna.com/about-us/
You know anyone on Substack, a webhost, podcaster, popular established blogger, other websites, share, let's get this ball rolling and make that link. If you know someone who died unexpectedly after getting the vaccine, contact them. This is so far the best potential lead to explain all those unexpected/unknown cases of death globally.