Increased sedation may occur if baclofen is taken acing on the central nervous system, alcohol or synthetic opiates. The n of respiratory depression is also increased. Combined treatme baclofen and antihypertensive is likely to increase the fall in blood pressure; therefore the dosage of antihypertensive medication should be adjusted accordingly. The concomitant administration of baclofen and tricyclic antidepressants may potentiate the pharmacological t quT effects of baclofen resulting in pronounced muscular hypotonia h patients with Parkinsons disease receiving treatment with baclofen and levodopa and carbidopa, there have been several reports of mental confusion, hallucinations, headaches, nausea and agitation STRET The concurrent use of MAO inhibitors and baclofen may result in increased CNS depressant effects. Caution is advised and the dosage rt of one or both agents should be adjusted accordingly. Caution should be exercised when administering baclofen and magnesium sulphate or other neuromuscular blocking agents since a synergistic effect TRR may theoretically occur.