Vitamina B1: Función neurológica.

Describo información sobre algunos roles que cumple la vitamina B1 o tiamina en los tejidos nerviosos. Es conocido que la tiamina cumple funciones coenzimáticas, no obstante, investigaciones realizadas por diversos autores sostienen que la tiamina se encuentra involucrada en funciones no coenzimáticas; comento sobre algunas de esas investigaciones.

Bâ, A. 2008. Metabolic and structural role of thiamine in nervous tissues. Cellular and Molecular Neurobiology. 28: 923-931.

Bettendorff, L. & Wins, P. 2013. Biological functions of thiamine derivatives: focus on non-coenzyme roles. OA Biochemistry. 1 (1): 10.

Bunik, V. I. 2014. Benefits of thiamin (vitamin B1) administration in neurodegenerative diseases may be due to both the coenzyme and non-coenzyme roles of thiamin. Journal of Alzheimer’s Disease & Parkinsonism. 4 (6): 1000173. 4 p.

Butterworth. R. F. 2006. Metabolism. Metabolic encephalopathies (pp. 594-602). In: Basic neurochemistry. Molecular, cellular and medical aspects. USA/UK: Elsevier Academic Press.

Cooper, J. R. & Pincus, J. H. 1979. The role of thiamine in nervous tissue. Neurochemical Research. 4 (2): 223-239.

Gibson, G. E.; Hirsch, J. A.; Fonzetti, P.; Jordan, B. D.; Cirio, R. T. & Elder, J. 2016. Vitamin B1 (thiamine) and dementia. Annals of the New York Academy of Sciences. 1367 (1): 21-30.

Iwata, H. 1982. Possible role of thiamine in the nervous system. Trends in Pharmacological Sciences. 3: 171-173.

Manzetti, S.; Zhang, J. & van der Spoel, D. 2014. Thiamin function, metabolism, uptake, and transport. Biochemistry. 53 (5): 821-835.

Mkrtchyan, G.; Aleshin, V.; Parkhomenko, Y.; Kaehne, T.; Di Salvo, M. L.; Parroni, A.; Contestabile, R.; Vovk, A.; Bettendorff, L. & Bunik, V. 2015. Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis. Scientific Reports. 5: 12583.

Saiki, M.; Matsui, T.; Soya, M.; Kashibe, T.; Shima, T.; Shimizu, T.; Naruto, T.; Kitayoshi, T.; Akimoto, K.; Ninomiya, S. & Soya, H. 2018. Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex. Scientific Reports. 8: 10469.

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