I've been looking into this as well, but mainly aimed at the steem platform, with all purchases using (transferable) steem or steem dollars. The Product or Service I provide would be limited to the country I am currently residing in.
This would just make life easier for me, no customs declarations, does the item comply with foreign standards etc etc. Definitely less hassle to the buyer as well.
RE: My experience selling on Instagram. Can I accept steem dollars?