The stems are vining or trailing in most species, though a few species from the Canary Islands have erect growth habits. Among some species, such as Ceropegia woodii, the nodes swell, and the roots similarly expand to form tubers beneath the soil surface. The leaves are simple and opposite, although they can be rudimentary or absent. Especially in certain succulent species, the leaves may also be thick and fleshy.
The flowers have a tubular corolla with five petals most often fused at the tips, forming an umbrella-like canopy, a cage, or appendage-like antennae.The flowers of this genus are adapted for pollination by flies. A great diversity of fly species are associated with ceropegias. The flowers are often inflated and fused at several points, forming a cage. Flies become momentarily trapped inside, accomplishing pollination as they move about.