By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Musculoskeletal Diseases and Conditions - Arthritis is the subject of a report. According to news reporting originating in Rennes, France, by NewsRx journalists, research stated, “To compare microvascular damages on nailfold capillaroscopy (NFC) with macrovascular manifestations evaluated by hand power Doppler ultrasonography (PDUS) in systemic sclerosis (SSc) patients, and to assess the associations of these damages with the main digital manifestations of the disease: digital ulcers, acroosteolysis, and calcinosis. NFC, hand radiographs, and PDUS were systematically performed in 64 unselected SSc patients.”
The news reporters obtained a quote from the research from University Hospital, “PDUS evaluation with assessment of ulnar artery occlusion (UAO) and finger pulp blood flow (FPBF) were performed blinded for the results of radiographs and NFC. UAO and pathologic FPBF were associated with severe capillary loss (<4 capillaries/mm) on NFC (odds ratio [OR] 4.04 [95% confidence interval (95% CI) 1.23-13.29]; p<0.05, and OR 3.38 [95% CI 1.03-11.05]; p<0.05, respectively). Digital ulcer history was associated with UAO (OR 10.71 [95% CI 3.36-34.13]; p<0.0001), pathologic FPBF (OR 7.67 [95% CI 2.52-23.28]; p<0.0001), late NFC pattern (OR 6.33 [95% CI 2.03-19.68]; p=0.001), and severe capillary loss (OR 8.52 [95% CI 2.15-33.78]; p=0.001). Acroosteolysis was also associated with UAO (OR 15.83 [95% CI 3.95-63.54]; p<0.0001), pathologic FPBF (OR 5.52 [95% CI 1.71-17.90]; p=0.003), late NFC pattern (OR 6.86 [95% CI 2.18-21.53]; p=0.001), and severe capillary loss (OR 7.20 [95% CI 2.16-24.02]; p=0.001). Calcinosis on radiographs was associated with late NFC pattern (OR 5.41 [95% CI 1.82-16.12]; p=0.002), severe capillary loss (OR 12.69 [95% CI 3.14-51.26]; p<0.0001), and UAO (OR 3.19 [95% CI 1.14-8.92]; p=0.025). Combination of UAO and severe capillary loss in the same patient was especially associated with digital ulcer history (OR 18.60 [95% CI 2.24-154.34]; p=0.001) and acroosteolysis (OR 10.83 [95% CI 2.56-45.88]; p=0.001).”
According to the news reporters, the research concluded: “Microvascular damages evaluated by NFC and macrovascular features like UAO assessed by PDUS show concordant associations with the main digital manifestations of the disease.”
For more information on this research see: Combination of Capillaroscopic and Ultrasonographic Evaluations in Systemic Sclerosis: Results of a Cross-Sectional Study. Arthritis Care & Research , 2017;():. (Wiley-Blackwell - http://www.wiley.com/; Arthritis Care & Research - http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2151-4658)
Our news correspondents report that additional information may be obtained by contacting A. Lescoat, CHU Rennes, University of Rennes and UMR INSERM U1085, Research Institute in Health, Environment and Occupation, Rennes, France. Additional authors for this research include G. Coiffier, M. de Carlan, C. Droitcourt, A. Ballerie, C. Cazalets, A. Perdriger and P. Jego.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1002/acr.23413. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
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CITATION: (2018-04-27), Researchers from University Hospital Report Findings in Arthritis (Combination of Capillaroscopic and Ultrasonographic Evaluations in Systemic Sclerosis: Results of a Cross-Sectional Study), Health & Medicine Week, 6951, ISSN: 1532-4605, BUTTER® ID: 015563224
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