Riot Games, creators of the latest Netflix hit, Arcane, has announced season II on all their social media. They did not yet announce a release date, but I don't think we'll see it earlier than 2023, as this kind of good animation takes a long time to make.
In the trailer we can hear the voices of Vi, Caitlyn and Jinx, implying that their stories continue next season too. The first season was s success hit, and ended with, SPOILER ALERT, Jinx getting a Pentakill on Piltover's council, but I still wonder if Jayce and Viktor survived, most likely they did. Perhaps next season we'll see Viktor augmented even more with the Hextech, and how he creates the suit that he is known for in the game.
With the arrival of Mel's mother and the introduction of Noxus, we could see next season more on Noxus and their conquest of Runeterra's World.