Huh, that shoulder struggle sounds familiar. For me, when I dealt with a tweaky knee from running too much on concrete, I started low like 250 mcg subQ near the spot, but after a couple weeks, bumping to closer to 400-500 daily seemed to make the real difference in how quick the soreness dropped off. Body size probably plays into it—I'm a bigger guy, so smaller doses just felt like they weren't cutting it sometimes. The link here has some decent thoughts on that kind of variation: https://speech-language-therapy.com/media/articles/bpc_2.html. Anyway, it's all trial and error in my book, and splitting doses morning and night kept things steadier than slamming it once. What route are you using mostly?