Cassia siamea - Barakol: A potencial anxiolytic

Cassia siamea (Cassodtree, Khilek, Senna siamea)

 Cassia siamea - Traditional Thai Medicine

In traditional Thai medicine, Cassia siamea has been used successfully over thousands of years to treat anxiety disorders, mild panic attacks, stress- and sleep disorders.
Nowadays, Cassia siamea is widely used in Thailand as an anxiolytic drug.
For general information look at:
http://www.phytopharmajournal.com/Vol3_Issue1_09.pdf
http://raincure.com/product/cassia-siamea/

In the year 1999, the results of a pharmacological study
on Cassia siamea were published.
The study results are publicly available on the Website http://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/275/359
According to this scientifical research paper review,
Cassia siamea is not toxic at usual daily doses (400mg-1600mg)
that justify it's wide use in folklore medicine.

 Barakol - A potential anxiolytic

According to another pharmacological study, the active constituent of C.siamea, Barakol, showed significant sedative and anxiolytic properties, similar to diazepam.
Barakol indeed has the profile of an anxiolytic drug.
It's anxiolytic activity has been shown particularly at low doses.
Have a look at:
https://www.ncbi.nlm.nih.gov/pubmed/8866982
http://www.sciencedirect.com/science/article/pii/0091305795020888?via%3Dihub

Note: In rare cases liver toxicity have been reported.
https://www.ncbi.nlm.nih.gov/pubmed/12930029
https://wwwlib.teiep.gr/images/stories/acta/Acta%20680/680_29.pdf

 Sources

http://www.phytopharmajournal.com/Vol3_Issue1_09.pdf
http://raincure.com/product/cassia-siamea/
http://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/275/0
http://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/275/359
https://www.ncbi.nlm.nih.gov/pubmed/8866982
http://www.sciencedirect.com/science/article/pii/0091305795020888?via%3Dihub
https://en.wikipedia.org/wiki/Senna_siamea
https://www.ncbi.nlm.nih.gov/pubmed/12930029
https://wwwlib.teiep.gr/images/stories/acta/Acta%20680/680_29.pdf
https://www.ncbi.nlm.nih.gov/pubmed/9042586