Speaking of "three highs", everyone is not unfamiliar, but the era of high uric acid known as the "fourth highest" has come. According to authoritative statistics, currently there are 120 million adult hyperuricemia patients in China. About one in 10 people suffers from hyperuricemia and the incidence rate increases year by year. It is followed by hypertension, hyperlipidemia, and hyperglycemia. Another metabolic disease.
How much do you know about the hazards of high uric acid?
What is terrible is that some hyperuricemia is not easily detected. People do not pay enough attention to hyperuricemia. If they are not discovered early and are not treated in time, they will induce a series of diseases such as gout, renal failure, and cardiovascular diseases. Inappropriate treatment, high uric acid will kill you!
What is uric acid
Uric acid is a purine in food that is absorbed and oxidized by the body. It is the waste of purine metabolism in vivo. 80% of purine is produced in the body, that is, it is released through cell metabolism, decomposed after exercise, and 20% of the outside world is dietary intake.
Purine is processed through the kidneys to produce uric acid into the bloodstream. The main kidney water can filter the waste in the bloodstream and generate urine through the bladder.
Why is uric acid high?
Under normal conditions, the body contains about 1200 mg of uric acid, and about 600-750 mg of uric acid is newly formed and ingested every day. At the same time, 600-750 mg is excreted in a balanced state of uric acid. Therefore, the concentration of uric acid depends on the absorption of purines and Decompose and excrete. The main reason for the high uric acid production is that it is produced in large quantities and excreted less.
Uric acid production
Ingested diets such as seafood, animal organs, seafood and other purine high foods produce more uric acid, and more importantly, endogenous, ie, uric acid produced by autoimmune defects.
Less uric acid excretion
As the kidneys are damaged, glomerular filtration capacity and renal tubular excretion are poor, resulting in poor metabolism of uric acid; at the same time, lack of gas, blood, high blood lipids, slow blood flow velocity, poor blood circulation of the extremities, resulting in uric acid Difficult to discharge, so uric acid will be high.
High uric acid, induced gout
High uric acid is of great danger, where uric acid sinks, where it hurts, and many diseases are closely related to it. It causes great pain to patients, and the first impression of high uric acid is associated with gout.
Science has confirmed that uric acid value is above 417, which belongs to hyperuricemia. One of 10 individuals will have gout. The higher the uric acid, the greater the probability of gout attack.
The onset of gout produces redness and thermal pain at the joints. Even without seizures, the uric acid crystals have been deposited on the joints, blood vessels, and interstitial areas of the kidneys. Just like the accumulation of silt, a long time will lead to the formation of crystals and even tophi. Joint deformity, toe pain, hands and feet can not move, dragging his legs can not walk, attack in the middle of the night, people do not want to be dying, even more will lead to life-threatening!
High uric acid, most damaged kidneys
Hyperuricemia is the most direct hazard to the human body.
Most of the uric acid produced by the human body is excreted from the kidneys every day. 90% of primary hyperuricemia is caused by decreased renal excretion, and hyperuricemia can cause acute urate nephropathy, chronic uric acid nephropathy, and uric acidity. In urinary tract stones, especially in patients with chronic nephritis, diabetic nephropathy, or hypertensive nephropathy, hyperuricemia can significantly promote the development of kidney damage, leading to renal failure until uremia.
High uric acid, combined with "three high" disease
Hyperuricemia and diabetes
Due to elevated uric acid levels, long-term deposition, damage to pancreatic β-cells leads to abnormal glucose metabolism, especially in people with risk factors for diabetes, promote the formation of type 2 diabetes, and high levels of uric acid are precursors of type 2 diabetes stroke, in turn, diabetes A long time has affected purine metabolism.
Hyperuricemia and hyperlipidemia
Hyperuricemia reduces the activity of enzymes that promote lipolysis, which in turn increases triglyceride levels, leading to dyslipidemia. An elevated level of triglycerides can also reduce the excretion of uric acid by the kidneys, which in turn leads to increased uric acid levels. Vicious circle.
Diabetes and hypertension
Studies have found that for each 5 mmol/L increase in blood uric acid, the risk of hypertension increases by 13%. Through uric acid activation of the renin-angiotensin system, vascular tone increases and blood pressure rises. Long-term accumulation of uric acid precipitates on the wall of blood vessels, which can damage the endothelial cells and cause thrombosis, leading to atherosclerosis, and a serious threat to life and health.
Hyperuricemia, induces cardiovascular disease
Hyperuricemia uric acid crystals, on the one hand, can increase the viscosity of blood, on the other hand will increase the adsorption of red blood cells on the surface, is conducive to the formation of thrombosis, urate also cause damage through the activation of oxygen free radicals, the formation of blood clotting, Urate is concentrated on the vascular wall and causes damage to the vascular endothelium. Long-term hyperuricemia accelerates the progression of atherosclerosis, increases the risk of stroke, increases the risk of stroke by 47%, and increases the risk of stroke death. 26%.
On the other hand, because of the long-term use of drugs, crystals that have already formed in human organs return to the blood vessels, blocking the smooth flow of blood vessels and causing cardiovascular diseases. This is very dangerous!