First answer these questions by Dr Garrow as follows:

1. How is it that small-pox is five times as likely to be fatal in the vaccinated as in unvaccinated.
2. How is it that, as the percentage of people vaccinated has steadily fallen from about 85 in 1870 to about 40 in 1925, the number of people attacked with variola has declined pari passu and the case mortality has progressively lessened? The years of least vaccination have been the years of least small-pox and of least mortality.
3. How is it that in some of our best vaccinated towns – for example Bombay and Calcutta – small-pox is rife, whilst in some of our worst vaccinated towns, such as Leicester, it is almost unknown?
4. How is it that something like 80 percent of the cases admitted into the Metropolitan Asylum Board small-pox hospitals have been vaccinated whilst only 20 percent have not been vaccinated?
5. How is it that in Germany, the best vaccinated country in the world, there are more deaths [from smallpox] in proportion to the population than in England – for example, in 1919, 28 deaths in England, 707 in Germany; in 1920, 30 deaths in England, 354 in Germany. In Germany, in 1919 there were 5,012 cases of small-pox with 6 deaths. What is the explanation?
6. Is it possible to explain the lessened incidence and fatality of small-pox on the same grounds as the lessened incidence and fatality of other infectious fevers – namely, as due to improved hygiene and administrative control? He finished his letter to the editor with these words: “There are just a few points in connection with the subject which are puzzling me, and to which I want answers. I am in doubt and I want to know the truth. Will some of the experts help me?”