So sorry to hear this!. The approach to this problem needs to be multi-pronged especially in view of the crises. He needs to have the back-up of a well set up immunology unit [which you seem to have] as well as a good holistic team. Glad the plasmapheresis helped. In the maintenance phase once the crisis has been seen through, there is a role for non-pharmacologic methods that can help address the root cause of the auto-immune dysfunction. May I ask where you live?