It depends... IMHO, you should never do something that you know will hurt someone else. Or offend, for that matter. Now, in the current climate, even saying something like "snow" can be taken as offensive. So if you take that as a guideline, it is hard to say anything at all. However, saying something that you know is, or could be, offensive, nah. But in that I believe that saying !DOOK is not offensive. You may not like it, you may not care, but it shouldn't hurt or offend you. Saying gdd*n for instance, could be offensive and hurtful for someone who is very religious.
Feel free to adjust my way of thinking here if you think otherwise! Always open to learn!
!DIY
!HOPE
!PIZZA
!INDEED
!ALIVE