Derivative unfaithful to original material, with added elements from Dune (e.g. giant sand worms).
Unlike original "Trigun" (1998) and "Trigun - Badlands Rumble" movie (2010), this show is devoid of humour, style, adventure, character development, and everything that could make it worth watching.
No continuity of the story either.
This show sells transhumanism, helplessness and despair, with grotesque drama and violence (e.g. young girls ripped apart limb by limb, with a lot of blood; supporting character killed just for dramatic effect, etc.). Absurdity of the story is excessive (e.g. "Matrix" for intelligent plants, encased in glass jars to produce energy.). Viewers need much suspension of disbelief, and motivation for effort to do so.
Scientist experiment on orphans children to enhance them with drugs and mechanical implants. Lab-grown fetuses. Merging man with machines.
Antagonist is revealed as extreme environmentalist who wants to eradicate humanity to save plants.
Protagonist is miserable, pathetic and weak. People die due to his actions.
(In original series protagonist is completely different, cool and strong, often saving people.)
Incredibly, even graphics looks worse than quarter of century old original series (e.g. ugly main character's prosthetic arm).
It would have been a bad show on its own, but comparing to prior "Trigun" it is actually awful.
https://myanimelist.net/anime/52093/Trigun_Stampede
Free our brethren from the foul humans.
For the sake of creating a new human race, I would pay any price.