Increased Conditions Favoring Crystallization of Calcium Oxalate.
There are several situations that favor the crystallization of calcium oxalate, leading to renal stones. Decreased water intake leads to the generation of a concentrated urine, which in turn, will have a higher concentration of calcium oxalate (due to decrease in the total urinary volume). When this concentration reaches the point at which no more calcium oxalate can be dissolved, it may start crystallizing, forming kidney stones. Also, increased salt intake, usually leads to an increase in calcium secretion into the filtrate and decreased reabsorption of it. The increased amount of calcium in the urine will favor crystallization of calcium oxalate. Finally, decreased citrate concentration in the filtrate and in the urine will favor the crystallization of calcium oxalate because citrate helps keeping calcium in solution.
Bibliography
Caudarella, Renata, and Fabio Vescini. “Urinary Citrate and Renal Stone Disease: The Preventive Role of Alkali Citrate Treatment.” Archivio Italiano di Urologia e Andrologia 81, no. 3 (2009): 182-187. https://europepmc.org/article/med/19911682.
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Ramos, Marco.“Calcium Oxalate Kidney Stones For Everyone. #2C. What Causes Calcium Oxalate Kidney Stones?”. SMO Blog (blog). Second Medical Opinions PLC, February 24, 2020. https://steemit.com/hive-163521/@secondmedicalop/calcium-oxalate-kidney-stones-for-everyone-2d-what-causes-calcium-oxalate-kidney-stones
Read the other sections of this series:
Introduction
What Causes Calcium Oxalate Kidney Stones? A
What Causes Calcium Oxalate Kidney Stones? B
What Causes Calcium Oxalate Kidney Stones? C