Well, I never played ME 2. I only started to play the first one but I didn't enjoy the beginning so I left it at that. Years later a friend told me about how cool this trilogy was so I decided to just go for the last one at that time, ME 3, and it was cool. After playing that game I concluded it would have been better to play the 1 and 2 first but it was too late by then.

About TES, I never played Oblivion :[ The only experience I had with RPGs when first playing Skyrim was only with Fable I believe... And Skyrim was much bigger and better in every way. Plus, the mods are so cool. You should try Enderal if you have the time btw. Absolutely a top-notch game, some people say it was even better than Skyrim itself but for me it was equal. With games such as TES mods are like half the fun.