Thanks to for the mention in its STEMng Digest, I am really happy and I am grateful for the mention. That said, let's begin with today's business. I was checking out a Whatsapp group yesterday, and I saw where people were referring to chicken pox and shingles as the same thing. You see, different people had different perspectives and they were right on their views seeing that some people do agree that chicken pox is shingles, and some said both are neither the same.
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Actually, those two shouldn't be the same as chicken pox is that itchy rash I had as a child, although I was not vaccinated. Oh, my dad was very worried because my mum wasn't around. I suffered lots of pain at that time, and I was running temperature all through. You see, that is one period I will never forget in my lifetime. Shingles on the other hand are blisters associated with nerve pain which occurs in adults.
One reason why I said people who proposed on the group that the both are the same aren't really wrong is because, both chicken pox and shingles are caused by the same virus, and the follow the same incident. They are caused by the herpes virus called varicella-zoster virus (VZV), and a lot of children still suffer from this virus and it was not until 1995 that the united state started given the Vaccine in infancy, so that tells you that a lot of other countries would have suffered from lack of proper vacination for a while. Because your body is able to fight the virus doesn't mean that the virus left your body. Trust me, the virus goes into a dormant state in the immune cells that fought it, so that means that I still have the dormant virus in me. You do not have to run away, because a lot of us house cetain weak viruses in our body from immunization.
So in the virus active stage, it is displays a lytic infection where the virus hijacks the host T-cells just to produce new virus that will make the host sick. I am feeling sick as I write, but do not worry, I will overcome this. In the lytic infectious state, the viruses are just going forth and multiplying (they must be religious or don't you think so?). When Herpes virus in the body switches to its latent phase, it does that in the host's peripheral nervous system and the ganglia, then it would not be active, it would multiply slowly. In this latency state, the cell could read a different viral gene over time. The virus uses ORF63 and ORF61 in the cell to maintain latency.
Over time, people who haven't had the shingle vaccine but have the virus in its latent phase would start to have shingles as the virus starts to read the ORF61 genes both backwards and forwards causing the backwards mRNA to stck to the forward mRNA. Varicella-zoster virus (VCV) remains in the neuron until older age and can cause shingles when it is active again. Similar to chicken pox, it causes a rash which is filled with blisters on one side of the body. This rash can come with burning sensation, tingling, and numbness, and when the rash is gone, the nerve pain can remain.
For me, I really need the shingles vaccine, because so many viruses do not leave our body after being treated, they go into dormant phase and for Varicella-zoster virus, it can become active which would lead to shingles. So when I say that both party have their points, then I am right since the ailment is caused by the same virus, following the same technique and even the same pathophysiology.