I have depression and medicate for it, 50mg a day of sertraline and it helps but some days are worse than others. It's not a simple fix. When I started taking sertraline tablets I got bad side effects with my stomach like diarrhea and had to stop, but since I got capsules it has been a lot better, I don't know why. Honestly the only side effects I feel now are numbness and headaches on and off but this is better than feeling miserable the whole time. I don't know if sertraline works well for me or if it is just a placebo impact but I definitely feel more happy after taking it. I don't take it every day however like I'm supposed to but on the grey days. It think it is still effective this way as it reduces the decline of sertraline in my brain and the impact lasts a few days (half like is around a day).
It also helps with some impluses and things like that, and reduce premature ejaculation somewhat too, so that's nice.