I've been using a stand-up desk for the last 3 months and feel a lot better. I take frequent breaks to go outside or do something--jumping jacks, play keyboard, bounce around, and to give my eyes a break from looking at the screen. I also wear glasses that protect my eyes from all that screen radiation. The glasses were only around $12 from Amazon.com but they have more expensive, yellow-tinted, orange-tinted glasses for about $78 that are supposed to work better. Since they have a good money-back guarantee, I'll probably try those.