Less is more! At least when it comes to stuff versus experience or quality of life. It is liberating to remove the excess burden of stuff. it can be hard but having to move all you own as you travel or just move to a new location will make the burden more obvious and help in the decision to lighten the load.
I find that it is a continues process that will never be completely finished. There are always things that were bought, or added for some reason, that soon just add clutter or burden and very little value. Still some things, like a ukulele, can be worth holding on to just for the promise of what it could mean if it was given more time.