#1: Make sure the fans do not have lights on them if the computer is in your bedroom, or they will keep you up at night.
#2: Take out a personal loan and maximize the RAM to its' highest level.
#3: There are never enough USB ports. Make sure they are all USB3, or put the USB2 at the back of the machine and all the USB3s at the front.

So...Win10 or Ubuntu Linux?