Researching the events of December 1531, it became clear to me what might have had happened and I sought some kind of confirmation. I found it here:
The Virgin of Guadalupe appeared in what is now Mexico City on the holy hill of Tepeyac, dedicated to Tonantzin, the Mother Earth goddess of the Aztecs. That is one reason why the bishop didn't believe Juan Diego. He must have thought: "We know who appears on that mountain and it's not the Virgin Mary but some pagan goddess!" Actually, the native Mexicans thought the same thing: "We know who appears on that hill: Tonantzin!" And so they referred to what we call 'Virgin of Guadalupe' as 'Tonantzin' for more than a century.
And, to confirm the above:
Scholar Jeanette Rodríguez, citing Xavier Escalada, notes "the Nahuatl language does not contain the letters d and g; therefore Our Lady's name could not have been "Guadalupe". She also presents the theory that Juan Diego and his uncle called the Virgin "Tlecuauhtlacupeuh", saying "The Nahuatl understanding of 'Tlecuauhtlacupeuh' is La que viene volando de la luz como el águila de fuego (she who comes flying from the region of light like an eagle of fire). The region of light was the dwelling place of the Aztec gods, and the eagle was a sign from the gods. To the Spaniards, it sounded like 'Guadalupe' and reminded them of their Virgin at home.
So here, as happened in European history, we have a renaming and adoption of an existing recurring non-natural event. In my humble opinion, a real being or communication from such. And thus 40 AD, the event in Spain, was by no means the first.
Just as a side note, the "house of Mary" was near Ephesus. A region of goddesses such as Artemis and Kybele.