Here is some disturbing research on brain problems caused by obesity in Mice. If this correlates directly to people, We will see that weight loss and brain function are directly tied together.
This also suggests that Drugs used to avoid synapse destruction, may also prove useful in treating immune attack type diseases. The immune attack disease that first comes to my mind is M.S.
This could be some promising research, and in the short term to other shoe to drop is the obvious need to limit weight to reduce the immune attack that is tied to extra weight in this study. Best case it will reduce these immune system attacks; worst case, you will loose some weight. Sounds like a win win situation to me!
:)