Brook, 31, has paved the way for a mega match-up with Khan, also 31, after knocking out Sergey Rabchenko, 32, last month in the second round.
Should Khan beat Canada's Phil Lo Greco, 33, tonight at Liverpool's Echo Arena all eyes will be on a mouth-watering clash between the two.
The duo have an ongoing feud and have been locked in a vicious war-of-words over the potential bout, and over who would come out on top.
Now Brook has ripped into the Bolton-born boxer over his astonishing Twitter meltdown last year when he accused his wife Faryal Makhdoom, 26, of moving on with British heavyweight king Anthony Joshua, 28.
Brook told Daily Star Online: "I don't know what goes through his mind, I don't know if it's real, not real. I call him Amir Kardashian.