The Israeli military said Iran fired rockets into the occupied Golan Heights.
About 20 rockets were fired by Iranian Revolutionary Guards and some of the rockets were successfully shed. The Israeli military added no casualties in the attack.
Earlier this week, Israel said its military was aware of "unusual activities" carried out by Iranian forces in the region.
The information made Israel order its troops on the Golan Heights to raise awareness and ask civilians to seek refuge.
The Israeli Defense Forces (IDF) said it had attacked dozens of Iranian military facilities in response to the rocket firing.
Syrian news agency SANA reported that Israeli missiles were shot down on the southern side of the city of Homs but an armory and radar installation were the victims of Israeli attacks.
SANA reported that two missiles were shot down in the Kiswah area and two civilians were killed in a delay.
However, UK-based human rights monitors for Syria (SOHR) say, Israeli missiles hit Iran's weapons depot and killed 15 pro-government fighters.
SANA added of that number delapam among them are members of Iran Revolutionary Guards and some non-Syrian people are among the dead.
Thousands of armed militia members, now trained and financed by Iran, are mostly Hezbollah members but others from Iraq, Afghanistan and Yemen.
The latest confrontation follows an Israeli missile strike report into a military post located on the southern side of the Syrian capital Damascus.
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