(2017-12-07), Encouraging oxygen’s assault on iron may offer new way to kill lung cancer cells, Women’s Health Weekly, 167, ISSN: 1532-4729, BUTTER® ID: 014779312
By a News Reporter-Staff News Editor at Women’s Health Weekly -- Blocking the action of a key protein frees oxygen to damage iron-dependent proteins in lung and breast cancer cells, slowing their growth and making them easier to kill. This is the implication of a study led by researchers from Perlmutter Cancer Center at NYU Langone Health, and published online November 22 in Nature.
Human cells contain 48 proteins that are known to depend on complexes of iron and sulfur to function. Dismantled whenever they encounter oxygen, these iron-sulfur clusters must be constantly replaced if normal cells are to survive in high-oxygen environments like the lungs, and even more so if lung cancer cells are to grow with abnormal speed.
The current study shows that lung adenocarcinoma cells survive this oxygen threat by producing more of a protein called NFS1, which harvests sulfur from the amino acid cysteine to make iron-sulfur …
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