Despite its pre-evolution Nidoran♀ and Nidoqueen's male counterpart Nidoking being able to breed, Nidoqueen and its pre-evolution Nidorina are unable to breed.
This also makes Nidorina and Nidoqueen the only two Pokémon that cannot breed even though their pre-evolution can breed.
Despite being in the Undiscovered Group, Nidoqueen was shown to be capable of breeding in the anime special Mewtwo Returns, when a cloned Nidoqueen and a cloned Rhyhorn produced Eggs containing both baby Rhyhorn and baby Nidoqueen (not baby Nidoran♀).
Nidoqueen is the only Nidoran evolutionary family member whose Shiny color is not the same as its opposite-gender counterpart's normal color.
Nidoqueen and its male counterpart Nidoking share their category name with Rhydon and Rhyperior. They are all known as the Drill Pokémon. All four are also Ground types.
Aside from Nidoking, no other Pokémon has the same typecombination as Nidoqueen.
In the Japanese games Pokémon Red and Green, Nidoqueen weighs 6.0 kg instead of 60.0 kg (as it does in all other games). This has no mechanical significance, as no game mechanics use weight in the handheld Generation I games.
