Just to level set, I am a Conservative that is generally frustrated with the 2 Party System. We have too many Politicians that have really have accomplished nothing in life other than entering politics and winning elections. And let's face it, once they win their first election, their subsequent elections are fairly easy to win. Incumbents almost always have a significant advantage over their opponents. This leads to career politicians that are numb to the real world and consumed with their Beltway Power. And they become loyal to their Party rather than the people that they supposedly serve. This leads to gridlock, empty promises, and self serving attitudes. And even if you are a "Never Trumper", you have to acknowledge that his Presidency has exposed much of what I am describing above.
That being said, many people are now questioning the possibility of Oprah making a run at the Presidency. I say why not? What made President Obama (or any other person) more qualified than Oprah? Absolutely nothing! I believe that she is just as qualified, if not more qualified than other Career Politicians. She has built an empire over the years without pissing anybody off or stepping on people (to my knowledge), she is a great communicator, and she has proven that she knows what it takes to be successful in a cut throat industry.
While at the end of the day, I probably won't agree with most of her opinions, but I don't think that disqualifies her as a viable candidate. And, much like Trump, I don't think that she is likely to be "bought and paid for" by special interests