DMT & the pineal gland: Origin of God, part 2, The science.
In part 1 I talked about the usage of DMT through out history and concluded that it have had a big influence on certain cultures. I concluded that calling it the Spirit molecule or God particle, is nothing strange. I advice you to read part 1 prior to this post, since i will tie back to it and try to prove or disprove the possibility that DMT stimulus generated many of the deities in older culture.
In part 2, or this part, I will review the scientific publications in hope to unravel how and where DMT is made and how it affects the brain, to see if there is any conclusions that can be drawn in regards to post 1.
Part 2: What do we know about DMT & the pineal gland?
How is DMT made in the body?
Quiet a lot actually! First of all many plants and animals produce the molecule known as DMT, N,N-DMT or N,N-Dimethyltryptamine which is essentially a two step modified Tryptophan.
The biosynthesis of DMT is very simple and could be done in a lab just as well. The reaction is part of the TRP metabolism, which looks like this:
The synthesis of DMT is dependent on the enzyme tryptamine-N-methyltransferase and for it to methylate the amine of Tryptamine. Tryptamine is made by another enzyme, a aromatic amino acid carboxylase, from the essential amino acid, tryptophan.
Another product of the pathway is seratonin, a neuron simulator, and the molecules are very similar, only the OH group of serotonin and methyl groups of DMT sets them appart. These modifications thou, have very large impact on receptor recognition, making DMT to be very rapidly broken down. It also gives rise to the legendary psychedelic effects of DMT.
I would also like to show a compassion between DMT, LSD and psilocybine sice they all share the aromatic core(ring structures) and are highly psychedelic in their nature. All can be synthesized by animals or plants as well as in laboratory settings.
I believe that these molecules have beneficial use on humans, such as antidepressants and I recently wrote about LSD as a micro dose antidepressant, check it out here! A big reason for suppressing studies on these compounds sure is that they would make the existent painkiller industry fail, they are highly non-addictive and have long lasting effects!
Is DMT produced by the pineal gland?
A very important question to answer right away, since the pineal gland and third eye / eye of Horus seems to be referred to in many ancient cultures. If the pineal gland indeed produces the DMT it would seem they had good knowledge on the are way back in Egypt.
We report here for the first time the presence of DMT in pineal gland dialysate obtained from the rat. However, the
method will permit the conduct of a range of future experiments, such as measuring possible circadian changes or performing dialysis studies in other brain tissues or in the ventricles. Regardless of the sample source, it is also important to be able to assess the effects of pharmacological treatments, such as MAO inhibition or other physiological interventions, on changes in the presence or concentrations of DMT and the other endogenous hallucinogens, their precursors and/or metabolites.
https://www.cottonwoodresearch.org/wp-content/uploads/2013/11/Pineal-DMT.pdf
Yes it seems so, as well as metabolites there of, pointing to the fact that oxidation of DMT might take place in the pineal gland in some extent at least, this study used rats btw. They found traces of IAA a known metabolite of DMT so the pineal gland seem to be involved.
I wounder why we have to use such advanced methods to prove it, if the ancient cultures knew about it, if..
Why do we have pineal glands?
It is a very small gland in the brain, responsible for producing melatonin, another similar compunds to regulate sleep cycles. It is involved in regulation heart beating as well, if I´m not mistaken. Both DMT and melatonin is part of our tryptophan metabolism, so there is nothing strange about this gland to be producing DMT as well.
What happens with the brain & body during DMT stimulus?
DMT and the sigma-1 receptor (S1R)
DMT has been seen to bind directly to the Sigma 1 receptor, a receptor that is involved in cell proliferation during oxygen deficiencies and is found through out the body, especially in the CNS. As I mentioned in post 1, Jesus could have suffered from oxygen deficiency when having a vision during the baptism ceremony. This could have induced activation of the Sigma 1 receptors, via DMT or just like DMT does, interesting!
This receptor is also proposed to be involved in schizophrenia and severe depression, maybe some DMT has positive effects. It was shown that DMT induces hyper-mobility in mice, bot not mice without the sigma 1 receptor.
Yeah we just found out that ecstasy is great vs post traumatic stress , FDA agrees, illeagle or not many of the drugs like DMT, LSD, ecstacy, amphetamine have or could have huge medicinal benefits!
5HTR1 & 5HTR2 receptors and DMT
Two receptors that is sensitive to serotonin which we know is very similar to DMT. Together, the 5HRT and Sigma-1 receptors modulate cognition and behavior as well as the earlier mentioned heart beat & sleeping cycles.
These receptors are mainly expressed in higher vertebrates and DMT also seem to be a very potent neurotransmittor.
EEG & DMT
Knowing which type of body functions the receptors of DMT might affect is not enough to explain its hallucinogenic properties, extreme hallucinogenic properties that is. It merely conclude that DMT is produced in our bodies and could have effects, passively, even thou we found such low doses of DMT in different body tissue / samples. It is also broken down very fast and studies looking at metabolites have drawn conclusions of higher DMT in the body, compared to blood & urine samples alone.
First of all, I saw this little 50 min documentary done by an neuroscientist using EEG and a patient that smokes DMT. He is doing some serious DMT smoking check it out!
A high level of gamma wave´s is obbserved, which I kind of hoped! Gamma waves is associated with a state of high understanding and integration without effort. Like monks doing compassion meditations or high level musicians listening to music, a high level of understanding! Could it be that the reality of gamma waves is more natural to us and this material reality is made from a slow learning procedure of pattern recognition, is not natural at all, but pure survival? Flow states are also linked to gamma brain waves.
Which brain waves exist and what are they associated with?
INFRA-LOW (<.5HZ)
DELTA WAVES (.5 TO 3 HZ)
THETA WAVES (3 TO 8 HZ)
ALPHA WAVES (8 TO 12 HZ)
BETA WAVES (12 TO 38 HZ)
GAMMA WAVES (38 TO 42 HZ)
Neuronal firing is interesting, since DMT acts as a neurotransmittor and gamma waves increase, provably. DMT seem to trigger a lot of neurotransmition over different brain areas making previously blocked communication in the brain possible.
The state we experience during DMT seem to be suppressed by our focus, beta waves, or our consciousness as we call it, that which thinks, analyzes and tries to stay alive. DMT acts as a doubble edged sword here and also suppresses alpha + beta waves and promotes gamma waves.
More on EEG patterns from humans affected by DMT
Another EEG study done by the Imperial college London, that comes with a video, gathered data from EEG and patient experience by giving the patients doses of 7,14,20 mg DMT intravenously.
They clearly report reduced alpha and beta waves massively all across the brain and a short time span. A peak in experience was achieved after 1 minute, lasting 5-7 minutes prior to wearing off.
The placebo group vs the DMT dosed patients is very clear and luckily none of the placebo patients experienced other dimensions or geometric patters :) That would have been cool thou!
Watch the full video report below
Lastly, QEEG STUDIES OF THE ACUTE EFFECTS OF THE VISIONARY TRYPTAMINE DMT, by Juan Acosta-Urquidi, PhD
This study tried DMT from 3 different sources. High purity synthetic 5-MeO- DMT, Bufo 5-MeO-DMT
(an extract from the Sonoran desert toad venom, Bufo alvarius), and N,N- DMT from a natural extract of the Acacia tree Mimosa hostilis root bark.
Reported lost alpha waves, increased waves in high beta or gamma 25+ and 30-40 hz. High synchronicity of the neurons
is seen and the only explanation of the experience is that the brain is functioning on a much higher level, effortless and with total unity.
The world around us is just built on expectations and pattern recognition, the brain never re iterate it all merely knows how it looks prior to seeing it. When the alpha and beta waves subside and gamma waves take over, we generate a reality of much less expectations and more based on fast neuronal activity, making it just as real I would say!
Is this reality just as real? since both the classic reality and the DMT induced one is based on neurons, but the DMT reality is made from hyper coherence and less expectations..... What do you think?
It seems very likely that DMT have had great effect on the ancient cultures and many of their deities. The effects reported and shapes experienced in scientific settings, matches well the ones described in ancient times. The pineal gland is producing and breaking down DMT, making it very central in DMT research and points to the fact that the eye of Horus sure could be relating to the pineal gland! Jesus, as stated, could have had his first vision during oxygen deficiency and activation of the sigma 1 or 5HTR receptors, just like DMT would.
What is reality?
Someone working on the reality and the fact that it is a hallucination based on only expectations is Seth Anil, a very interesting scientist!
The brain could never generate all of reality instantly, but already expects it to be there and all our scenes do is verify the reality we expect. We could never use sight and sound impressions to generate the reality instantly, it would take time and we would have a lag.
Perhaps DMT alters the possibility of the brain to expect reality as we have learned, and simply shows us what is there, hyper connectivity wouldn't lie no would it? Remember if we do not have a single idea or thought of a thing, we can´t see or experience it.
It is not that strange since we know that the brain can quickly change what we see and hear when the information the brain have changes, which it does in a sense via taking DMT. The same sensory information comes in during DMT trips but it is iterated faster and through out all the brain, interesting indeed!
Is there a body and brain at all, or what is hallucinating reality? Remember the brain and body is simply parts of a hallucination, we could be anything, a simulation or single cells communicating in a pound of water!
No one knows, but it seems that the hallucination is controlled in a fashion to do everything to stay alive. We cant even prove consciousness, cool huh! Are we dimension less, time less and eternal, generating this experience of the brain, in that case why? why not stay in unity and eternity? I would say to create free will, which i wrote a bit about already but will again soon, stay tuned for the follow up!
Thanks for checking my post out, much appreciated!
