This was a constant question throughout my 20's. The answer for me was that no one knows what I should do with my life outside of myself. Only I know what I should do with my life. No one else could possibly have a genuine clue as to what I should do other than me because I am me and this is my life. No one knows what's better for me--than ME.
I needed to learn to trust myself and have confidence in my own decisions even if they seemed like mistakes in hindsight, because there are no mistakes, just choices that I will learn from to better define who I am what I am seeking.
Trust yourself.