Spurs beat Arsenal 2-0 in the last ever north London derby to be held at White Hart Lane back in April, and need a similar result this time around at their temporary home of Wembley Stadium.
The London rivals sit fifth and sixth in the Premier League table heading into Saturday's early kick-off, and defeat for either side could leave their top-four hopes in dire straits.
But both teams head to Wembley in confident mood, with Mauricio Pochettino's Spurs taking four points off of Manchester United and Liverpool while Arsene Wenger's new-look Gunners blew away Everton 5-1 at the weekend.
ARSENAL TEAM NEWS
Arsenal could be without Petr Cech. The experienced goalkeeper was forced off in the win over Everton with a calf problem and has not trained since as David Ospina prepares to deputise.
Nacho Monreal also came off in that 5-1 victory due to illness but should be available to retain his place while Danny Welbeck (hip) is back in contention. Santi Cazorla (Achilles) remains a long-term absentee.
Provisional squad: Cech, Ospina, Macey, Mertesacker, Holding, Mustafi, Koscielny, Chambers, Monreal, Mavropanos, Bellerin, Nelson, Kolasinac, Maitland-Niles, Wilshere, Xhaka, Elneny, Ramsey, Ozil, Iwobi, Welbeck, Mkhitaryan, Aubameyang, Lacazette.
SPURS TEAM NEWS
Mauricio Pochettino has no injuries to contend with.
January signing Lucas Moura could make the squad after working on his fitness this week while Toby Alderweireld is in line to start after playing 90 minutes against Newport on Wednesday.
Harry Winks, Serge Aurier and Danny Rose all returned in the FA Cup fourth round in midweek and are also in contention.
Provisional squad: Lloris, Vorm, Gazzaniga, Rose, Davies, Walker-Peters, Vertonghen, Alderweireld, Sanchez, Dier, Foyth, Aurier, Trippier, Wanyama, Sissoko, Winks, Dembele, Oakley-Boothe, Alli, Eriksen, Son, Lamela, Llorente, Kane.
PREDICTED LINEUPS:-
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Tottenham starting XI: Lloris; Trippier, Alderweireld, Vertonghen, Davies; Dembele, Dier; Alli, Eriksen, Son; Kane!
Arsenal starting XI: Ospina; Bellerin, Koscielny, Mustafi, Monreal; Ramsey, Xhaka, Iwobi; Ozil, Mkhitaryan, Aubameyang
