One can only achieve greatness once its insignificance is properly perceive and understood. To be great is to be aware of the immensity of our universe, is to embrace complexity and perceive things in a systematic way, once you see how big the world is and how little your presence in it make a difference you can start to perfect yourself in order to achieve the maximum of your limited capacity.
We are constantly planning, and the brightest minds of our time often show a great amount of optimism, that I consider unwarranted to say the least. I read articles about the possibility of travel faster than light and explore planets beyond the solar system, but that seems very unlikely to happen, I think the human species will die trapped in the solar system. I have the same skepticism about the emergence of conscience in AI, I think is something that can happen, but is not inevitable. My main point of disagreement with those who believe in the inevitability of a conscious AI, is that as far as we know conscience is something that required the ability the fell something, conscience without feeling has no meaning.
To sum up, I think we must be aware of our insignificance in order to prevent all the damage cause by our hubris and to truly know ourselves and our real possibilities of fulfillment.