A systematic review of omega-3 fatty acid health related studies has shown supplements (Fish oil) have little benefit on heart issues, stroke, and death. Omega-3 fatty acids involved with human physiology are α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Mammals are unable to synthesize omega-3 fatty acids, but obtained in a regular diet. Fish oil is promoted as a protective supplement for heart health despite any significant evidence. The fish oil industry brings roughly 2.3 billion USD per year and is likely to increase. The study published in the Cochrane library reviewed seventy-nine randomized trials