This is an awesome write up for a newbie (I presume from your profile). I guess suesa did some tutoring beforehand.

Your article is an interesting one for me, considering the fact that I have once worked as a pharmacy technician for some months.

Lemme start with your definition of of pharmacokinetics:

pharmacokinetics = the effect of the organism on a drug taken over time

Perhaps you mean the other way round. In this case, it should be the effects of the drug taken on the organism over time and not vice versa.

Then I have a question: what are probands? Who qualifies/volunteers/get selected as probands? What if the drug has deleterious side effects on these humans?