Great post! Resteemed. I'm looking forward to reading more ;).

Recently I have come across two really interesting articles regarding the CRISPR-Cas9 system. The first is connected with the potential immune response of the human body to Cas9 proteins. The currently used homologs are derived from Staphylococcus aureus and Streptococcus pyogenes, so it is possible that the pre-existing adaptive immune responses can occur due to the contact of human population with those bacteria.
Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans

The second describes the amazing possibility to modify the epigenome by bounding the Cas9 with an additional catalytic domain.
The epigenome: the next substrate for engineering