Well...I will try to make clear answer :)
Ovariectomy by itself caused the decrease in PR expression in satiety brain regions, contrary to feeding for reward regions in which there is an increased expression. Stress by itself does not affect those regions in the brain. When combined with ovariectomy, stress response nullified ovariectomy and brought levels of steroid hormone receptors to those common for that age or even higher.
Ovariectomy and chronic stress downregulated the levels of ObR in satiety brain regions. Combination
of ovariectomy and stress reversed individual effects and led toward significant upregulation of ObR in hypothalamic satiety centers.
And please be aware that in this study we analyzed insulin and leptin receptors, not insulin and leptin.
Hope you are littl bit less confused now :)
RE: Our study - chronic stress lead toward leptin and insulin resistance in the brain