Bologna's first goal of the season was worth the wait, and led to a surprise victory as Filippo Inzaghi's team upset Roma 2-0.
Filippo Inzaghi's Bologna kept the pressure on Roma
Bologna hadn't scored in their previous four matches but the hosts got off the mark in stunning fashion 10 minutes before half-time.
Robin Olsen only flapped at Sebastien De Maio's cross and the ball came through to Federico Mattiello near the byline. He cut back, before curling a finish into the far side of the net.
Lorenzo Pellegrini should have equalized on the stroke of half-time but blasted over with an open goal and Bologna doubled their tally just before the hour mark.
Federico Santander raced from inside his own half to collect Diego Falcinelli's pass and finish off a swift counter-attack.
Roma have not won since the opening day of the season and lost 3-0 at Real Madrid on Wednesday.
Lorenzo Insigne scored twice to help Napoli win 3-1 at Torino in a dominant performance from last season's runners-up.
Torino gifted Insigne the first goal with less than four minutes on the clock. Emiliano Moretti attempted to clear Sebastiano Luperto's cross but it came off Torino teammate Nicolas N'Koulou and straight into the path of Insigne, who drove it in under the crossbar.
Simone Verdi doubled Napoli's lead in the 20th minute with his first goal since joining from Bologna in the summer. The Italy forward started the move in midfield before passing to Dries Mertens on the left and racing into the area to fire in the return pass.
Torino got back into the game when Andrea Belotti converted a penalty early in the second half after Alejandro Berenguer had been brought down by Luperto.
However, the hosts gifted Napoli another easy goal shortly afterwards. Armando Izzo lost possession in midfield to Marek Hamsik, who picked out Jose Callejon. The Spaniard's shot came off the post but Inisgne was on hand to tap in the rebound.
It was Insigne's third goal in two league matches, following a slow start to the season.
Giacomo Bonaventura scored against his old club but AC Milan was held 2-2 by Atalanta following a stoppage-time equaliser from Emiliano Rigoni.
Gonzalo Higuain had volleyed in the opener after 90 seconds for Milan before Papu Gomez levelled early in the second half.
Bonaventura, who also had a goal disallowed on video review, and Higuain both hit the post.
Elsewhere, Lazio picked up their fourth victory in all competitions with a 4-1 win over Genoa, while Udinese won 2-0 at Chievo Verona