Having suffered heavy losses in both Tests and all three one-day internationals, the visitors will be targeting the two T20s, in Bloemfontein and Potchefstroom, against a much-changed Proteas' side to end their tour on a high.
Captain JP Duminy remains wary of the opposition, with Robbie Frylinck potentially being handed his debut in amongst an inexperienced South African bowling attack.
"It could be a dangerous thing - in that they have nothing to lose," the 33-year-old said. "Or they could have one foot on the plane already and want to go home."
Although Mashrafe Mortaza has retired from the format, captain Shakib Al Hasan has an experienced side to call upon and he believes the shorter format will suit his side more.
"I think it is such a short format that we don't have much time to think about things, which is to our advantage," Shakib said.
"In Tests and ODIs there's a lot of time to think, which leads to a lot of complicated thinking. If everyone can keep things simple, we can leave with a good performance."
Watch the first Twenty20 between South Africa and Bangladesh live on Sky Sports Cricket (channel 404) from 4.55pm on Thursday and from 5pm on Sky Sports Main Event (channel 401).