This is a Dragon Cargo mission to resupply the ISS from Space Launch Complex 40 on the Cape Canaveral Air Force Station.
The Dragon Capsule launches for the second time and sits atop a new Falcon 9 Block 5.
Launch window opens at 18:16 UTC (December 5th 2018).
You can watch the live stream here. Approximately 15 minutes before lift off.
Background information about previous launches at Wikipedia
The first stage of the Falcon 9 will attempt a landing on land at Landing Zone 1.
When: 18:16 UTC
You can check your local time here:
https://www.timeanddate.com/worldclock/fixedtime.html?msg=SpaceX+CRS+-+16&iso=20181205T1816&p1=%3A
You can use a bot to remind you by leaving a comment like this:
@remind-me on 5nd December 2018 18:00
The bot will notify you by commenting under your comment at the set time.
Sincerely,